The Art to Manage diabetic Foot Infection Focus : on Ertapenem (INVANZ®)

The Art to Manage diabetic Foot Infection
Focus : on Ertapenem (INVANZ®)

Diabetes is a serious chronic disease. In 2003 the global prevalence of diabetes was estimated at 194 million. This figure is predicted to reach 333 million by 2025 as a consequence of longer life expectancy, sedentary lifestyle and changing dietary patterns. This rise is to bring a proportional increase in the people with diabetes complications, including problems of the foot.
Diabetes mellitus is a disorder that primarily affects the microvascular circulation. In the extremities, microvascular disease due to "sugar-coated capillaries" limits the blood supply to the superficial and deep structures. Pressure due to ill-fitting shoes or trauma further compromises the local blood supply at the microvascular level, predisposing the patient to infection. The infection may involve the skin, soft tissues, bone, or all of these tissues. Diabetes also accelerates macrovascular disease, which is evident clinically as accelerating atherosclerosis and/or peripheral vascular disease.

The Cinula® is More Than Rationale Therapy in Diabetic Polyneuropathy

INTRODUCTION The Cinula® is a novel FDC of cunnulin PF 250mg, ALA 300mg Vit B12 100mcq, and Chromium (Cr), which has multiple therapeutic values for patients with obesity, prediabetes, the MetS, and T2DM. It can be used pathogenetically for patients with diabetic polineuropathy and oxidative stress (smoker etc). The link between increased body fat and insulin resistance has been generally recognized and accepted. It has become apparent that insulin resistance is actually associated with the increased in body fatness. The body composition of regional adipose depot-total body fat, deep subcutaneous fat, visceral fat– contributes most frequently to insulin resistance, and then prediabetes and the metabolic syndrome (the MetS) may pursue. The cinula®, the novel FDC cinnulin PF, ALA, and Vit B12, has biologic effects on body composition and prediabetes (Zeigenfuss et al 2006, 2007). The MetS is a “good example” of lifestyle related preclinical disease, and is an insulin resistant state associated with increased cardiovascular disease (CVD) risk. The MetS is usually been flanked by cardiometabolic risk factors, including various combinations of abdominal obesity, glucose intolerance, atherogenic dyslipidemia, hypertension prediabetes, and associated with a high risk of developing T2DM. The cinnamon extract has been demonstrated to improve the plasma glucose, A1C, and serum lipid of patients with T2DM (Khan et al 2003, Mang et al 2006, Zeigenfuss et al 2007). Antioxidant effects of a cinnamon extract in overweight or obese people with impaired fasting glucose have been studied by Roussel et al (2006). Alpha-lipoic acid (ALA), built in the cinula®, has antioxidant effects and has been demonstrated to be successful in the treatment of diabetic polyneuropathy, diabetic patients with insulin resistance, oxidative stress, hypertension, dyslipidemia and cardiovascular disease (Zeigler et al 2003, Midaoui et al 2002, Ametov et al 2003, Wollin et al 2003, Sola et al 2005, Young et al 2006). Vitamin B12, one component of the cinula®, has important roles in the treatment of diabetic neuropathy and also shows a pivotal role in the cognitive function. Chromium (Cr) content exists in the cinnamon, and it has been widely reported to play a role in the control of blood glucose of patients with diabetes mellitus which are due to its effects to improve insulin receptor and post receptor function.

Cured AIDS sufferers because Blood Cell Transplantation

A blood cell transplantation is quite rare most likely to cure men with AIDS in Berlin, Germany. However, team doctors said that this method can not be practiced widely.

40-year-old man with AIDS is getting blood stem cell transplant to treat leukemia in 2007 he suffered. Apparently it's not just the same donor blood type, but also affects the genetic mutation that provides natural resistance to HIV (the virus that reduce the human immune system). Now, three years post-transplant, people with AIDS showed no symptoms of leukemia or HIV infection.

"Therapy is quite interesting and provide evidence of cure HIV, but the method is too risky to be a standard therapy, even if a similar donor can be found," said Dr. Michael Saag, former chairman of the HIV Medicine Association, a medical organization that specifically deal with AIDS therapy.

Acquired HIV from Kidney Donor

A kidney transplant patient contracted HIV from living donor kidney given. This case represents the first documented case in the United States since HIV screening was introduced in the mid-1980s.

Mentioned that kidney donors are not safe sex 11 weeks before HIV test results are negative. Kidney transplant operation was conducted in 2009 and became known only a year later the patient was HIV positive.

The Center for Disease and Prevention (CDC) recommends screening for infectious diseases such as HIV or hepatitis in donated organs that would be repeated a week before the transplant operation. But many foreign transplant organization in the country that does not rule out exactly when screening should be done.

Against HIV with the virus

Leor Weinberger biochemist from UC San Diego uses unorthodox approach to combating the spread of HIV / AIDS: the virus against viruses.

Weinberger and his colleagues in San Diego and UCLA make the ride on HIV particles. As HIV moves into someone else and be in the cell, the virus that will compete with HIV.

During simulation, the researchers found that the therapy is called "therapeutic interfering particles (TIPS)" This reduces the number of people infected with HIV-third of the twenty-conditions now.

TIPS is made from a harmless part of HIV by eliminating a key part of genetic information, such as how to duplicate themselves. In order to survive, TIPS using DNA from the original virus to replicate, which means that TIPS can not live without HIV.

Found, Cheap Ways Making Malaria Drugs

Experts in Canada and the United States claimed had found the process of making malaria drugs faster and cheaper. They found a way to make artemisinin, the main content in some malaria medicines, using yeast, genes, and fermentation. The researchers say that this way better and more efficient than extracting artemisinin from the plant.

Researchers from OneWorld Health, Amyris, Unversity of California at Berkeley, and the Canadian government, to identify genes that produce artemisinin at generating plants. Then they tried the gene in yeast and make them artemisinin in the lab.

"This technique makes more production doubled and faster,"explained the researchers.

Minister of science and technology Gary Goodyear Canada said that these developments represent a major advancement in the fight against the disease. "Reaffirming Canada's position as a provider of health solutions that reliably and inexpensively," said Goodyear told The Star Phoenix.

Sleep Late at Night Can Trigger Sudden Death

The bustle often make many people become lost in, including matters rest. It is not unusual for people in this modern era, especially in urban areas, always sleep late and have to get up early morning.

Not many are aware when these habits can cause very bad effects on health. Sleeping too late that causes minimal time berisitirahat become real potential to become a new and deadly threat.

A recent research study shows, the lack of time berisitirahat at night can trigger the risk of heart disease and stroke. Research experts from Warwick Medical School, published in European Heart Journal suggests, sleeping less than six hours a night can increase the risk of death from stroke by 15 percent and the risk of death from heart attacks jumped by 50 percent.

Can not Sleep Is Beginning Of Mental Disorder

Did you ever have trouble sleeping? I once and it was very uncomfortable. In the morning we can not move up to and feel this is the wrong agency.

Although only a day I feel unable to sleep, but the feeling is very excruciating. No wonder I really understand the suffering of the patients who complain of difficulty sleeping even close for weeks.

Initial mental disorder

It's hard to sleep even though it sounded trivial, but in my daily practice is often a sign of an underlying psychiatric disorder condition.

Almost rarely I find it difficult to sleep standing alone as a disorder without psychiatric disorders. Usually people who complain of trouble sleeping most of the experience mental disorders include anxiety disorders, depression, dementia and psychotic disorders (mostly schizophrenia).

Afternoon Sleep Can Adverse

Adequate sleep is essential for maintaining physical and psychological health. Closed his eyes for a moment during the day also effectively repel feeling tired. But not all people are advised to take a nap because it can hurt.

If you do not have a problem with sleep at night, take a moment to sleep in the daytime it can give positive benefits. Research in 2008 showed 45-minute nap can improve memory function, lowers blood pressure and relieve stress.

Ways to Prevent Colon Cancer

In addition to early diagnosis, one of the best approach in the fight against cancer is prevention. In cases of colorectal cancer (colon), the evidence shows was largely because dietary factors.

Whatever your age, it's never too late to do anything that might prevent the occurrence of cancer. Here are some factors that cause colorectal cancer that we can still control:

1. Contact with certain chemical substances such as heavy metals, toxins, ototoksi, as well as electro-magnetic waves

Modern Diet Causes Colorectal Cancer

How do you know about colorectal cancer? The term colorectal cancer associated with organ large intestine (colon) and final disposal intestine (rectum). Colon cancer (colon) and intestine final disposal has much in common. Therefore, often jointly referred to as colorectal cancers.
This cancer is the world's third largest cancer types in terms of number of sufferers. Colorectal cancer is a leading cause of death du world number two, where the factor of age also influence. According to data from the World Health Organization (WHO), an estimated 700 thousand people die from colorectal cancer each year.
Normally, this increases the risk of suffering colorectal sharply after the age of 50-55 years. One of the precautions that can be done to avoid these cancers is by eating healthy.

DIABETES AND METABOLIC POLYNEUROPATHY: FROM STUDIES TO CLINICAL PRACTICE

Diabetes Mellitus (DM) is estimated by WHO in 2000 has a prevalence of 150 million, and in 2030 is expected to increase by 366 million (Wild et al., 2004). Neuropathy is a very common complication characterized by symptoms characteristic of the loss of peripheral nerve fibers in a progressive (Boulton et al., 2004). There are several clinical manifestations including mononeuropati neuropathy or polyneuropathy. In DM patients the common people with diabetic foot is the distal sensory polyneuropathy. Even so often accompanied by disturbances of motor and autonomic nerve fibers. The occurrence of neuropathy associated with poor glycemic control, and the incidence generally increased with increasing age and longer duration of DM.

DM clinic descriptive research profile on Installation Diabetes Outpatient Clinic at Hospital Dr.Soetomo of 51% (1333 of 2609 people) DM patients have complaints incidence of peripheral neuropathy and / or parastesia. In patients in the Inpatient Ward Hospital Medicine Section Dr.Soetomo recorded 90.03% of neuropathy in diabetic patients with diabetic foot complications (Soegiarto et al, 1998).
Data epidemiology and course of the disease Diabetic neuropathy showed varying numbers, and is a common medical problem faced by patients. Several studies neuropathy prevalence in outpatients is estimated that 30% (Young et al., 1993), while the prevalence in the general population is estimated to 20 (Kumar et al., 1994; Cabesas, 1998; Abbot et al., 2002; Walters et al., 1992; Dyck et al., 1993; Boyko 1998). In old age the prevalence could reach 50% (Boulton et al., 2004; Kumar et al., 1994). In a variety of population prevalence rate ranging from 14% to 63% depending on the criteria of neuropathy dipergunskan (Walters et al., 1992). In EURODIABIDDM Complications Study (Tesfaye et al., 1996) with a total sample of 3250 patients, the mean prevalence rate of neuropathy in 16 European countries reached 16%. In the Rochester Diabetic Neuropathy Study Study (Dyck et al., 1993), reported a 60% neuropathy patients, although only 15% are symptomatic.
This paper briefly discussed the development of pain management and treatment of symptoms associated with Diabetic Neuropathy.

HYPERTENSION IN METABOLIC SYNDROME: WHAT IS THE ROLES OF IRBERSARTAN

Metabolic syndrome (Mets) or syndrome Dismetabolik or Resistance Syndrome is a term for a group of disorders with different clinical consequences, which is characterized by: impaired glucose tolerance, insulin resistance, dyslipidemia, hypertension, coagulation abnormalities and visceral obesity (Tjokroprawiro, 2005). All co-morbid factors above in synergy to cause atherosclerosis early, so that the individual has increased risk of developing heart disease and blood vessel (Schunkert 2002).

IMMUNE RESPONSE TO MALIGNANCIES

ABSTRACT
When immune cells and developing tumor cells localize to a common microenvironment, an assemblage of interaction takes place. This results in either tumor destruction by way of immunosurveillance or tumor outgrowth.
Immune response to tumor associated antigens exist in tumor bearing hosts but are usually not successful in eliminating malignant cells or preventing the development of metastases.
Tumors are genetically unstable, and the emergences of genetic variants ensures that the tumor survives in the face of the host immune system. It is likely that tumor cells recognized by the immune system are eliminated as they arise, and only those tumor cells that manage to foil the immune surveillance escape and survive.
However, another studies suggest that the immune system can also actively promote formation on certain tumors. These apparent disparate effects of immunity on tumorigenesis provide a unique model for study of the decision-making process that dictates immune function within a tumor.
In this review, we will discuss the concepts that the panoply of immune system-tumor cell interactions that have been reported are non-mutually exclusive combinations of various positive and negative forces in action, with the protective actions of immunity being the best possible result and the tumor-promoting immune actions being the worst.